منابع مشابه
Tumor-derived VEGF modulates hematopoiesis
VEGF-induced angiogenesis significantly contributes to tumor growth, invasion and metastasis. However, little is known about its hematopoietic activity during malignant development and progression. Here we show that in a mouse tumor model, tumor-derived VEGF acts as an endocrine-like hormone to induce extramedullary hematopoiesis by targeting distal organs in the host. In tumor-bearing mice, ci...
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Curcumin, a natural polyphenol compound from the perennial herb Curcuma longa, has been proved to be beneficial for tumor-bearing animals through inhibiting tumor neovasculature formation, but the underlying mechanisms are unclear. Here, we aim to test whether curcumin affects VEGF-VEGFR2 signaling pathway and attenuates defective hematopoiesis induced by VEGF in tumor model. We demonstrated th...
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In this issue of Blood, Rafii et al present an elegant study of human embryonic stem cell (ESC)–derived hematopoiesis incorporating live imaging at the single-cell level to track hematopoietic lineage potential during the endothelial to hematopoietic transition.
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We recently reported that local overexpression of VEGF-A in white adipose tissue (WAT) protects against diet-induced obesity and metabolic dysfunction. The observation that VEGF-A induces a "brown adipose tissue (BAT)-like" phenotype in WAT prompted us to further explore the direct function of VEGF-A in BAT. We utilized a doxycycline (Dox)-inducible, brown adipocyte-specific VEGF-A transgenic o...
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Based on successful preclinical data, over twenty antiangiogenic agents, alone or in combination with conventional therapies, are now in clinical trial. In the year 2000, close to 1,000 manuscripts describing the basic molecular and cellular mechanisms that allow for an angiogenic response have been published. The goal of this review is to summarize the reasons that angiogenesis re s e a rch ha...
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ژورنال
عنوان ژورنال: Journal of Angiogenesis Research
سال: 2009
ISSN: 2040-2384
DOI: 10.1186/2040-2384-1-9